Kitmondo is your go-to marketplace for premium used industrial machinery. In our Pharmaceutical and Chemical category, we proudly feature a range of lyophilizers and freeze dryers, each carefully maintained to offer exceptional efficiency, precision, and value.

Our lyophilizers and freeze dryers are essential for preserving and stabilizing sensitive biological and chemical materials by removing water content through sublimation. Perfect for applications in pharmaceuticals, biotechnology, and food processing, these machines maintain the integrity and shelf life of products like vaccines, biologics, and dehydrated foods.

Each lyophilizer and freeze dryer in our selection undergoes a rigorous vetting process to ensure superior quality and performance. Our equipment provides substantial cost savings compared to new machinery while maintaining high efficiency. We showcase trusted brands like Virtis, SP Scientific, and Telstar, celebrated for their dependability and advanced technology. Prices range from €20,000 to €150,000, accommodating a range of budget requirements.

For more detailed information or to request a quote, please reach out to our dedicated team, who are ready to assist with your specific needs. At Kitmondo, we focus on driving your business growth with top-quality, affordable machinery. Trust Kitmondo for your pharmaceutical and chemical equipment needs and see your productivity soar.

terruzzi 6 mq Lyophilizer

Year: 2000

Chamber volume -6 L
Freeze trap capacity 90 L
Nbr of trays 6
Tray surface 1 m²
Minimal T° 60 °C

EDWARDS MOD 1700 Lyophilizer

Year: 1980

Chamber volume 20 L
Freeze trap capacity 5 L
Nbr of trays 2
Tray surface 0.2 m²
Minimal T° 40 °C

Freeze Dryer for Sale (Steris GT500)

Year: 2002

Chamber volume 11500 L
Nbr of trays 19
Tray surface 3.34 m²

HOF GT laboratory freeze dryer / Lyo (2,16 m2) for vials with „stoppering“

Year:

Chamber volume 645 L
Freeze trap capacity 2.2 L
Nbr of trays 6
Tray surface 0.36 m²
Minimal T° -80 °C

mp 20 kg Lyophilizer

Year: 5

Used Lyophilizer 20 kg 6 trays semi-new visible in Italy

SERAIL CS15-1 Lyophilizer

Year: 2009

Chamber volume 683 L
Minimal T° -65 °C
Tray surface 1.02 m²
Nbr of trays 4

LYOMAC FREEZE DRYER Low working hours

Year: 2014

Chamber volume 2000 L
Freeze trap capacity 100 L
Nbr of trays 15
Tray surface 1.08 m²
Minimal T° -75 °C

CUDDON LTD FD80 LT/T Lyophilizer

Year: 2005

CUDDON FD80 LT/T freeze dryer WHICH WAS VIRTUALLY ENTIRELY REMODELED IN 2017 by Coolvacum

Usifroid SMH 301 Lyophilizer

Year: 1986

Tray surface 5.46 m²
Nbr of trays 7
Minimal T° -70 °C



OPTIMA FD D29 FREEZE DRYER

Year: 2015

Chamber volume 10582 L
Minimal T° 130 °C
Tray surface 28.5 m²
Nbr of trays 16

Edwards MINI-FAST 1700 Lyophilizer

Year: ~ 1980

Minimal T° -80 °C
Nbr of trays 3

Usifroid SMH Lyophilizer

Year: 1998

Tray surface 28.8 m²
Nbr of trays 15
Freeze trap capacity 10 L

Usifroid SMH Lyophilizer

Year: 1998

Tray surface 28.8 m²
Nbr of trays 15
Freeze trap capacity 10 L

Used OPTIMA FD D29 Lyophilizer

Year: 2015

Chamber volume 10582 L
Minimal T° 130 °C
Tray surface 28.5 m²
Nbr of trays 16



USIFROID SMH1500 Lyophilizer

Year: 1990

Chamber volume 6500 L

USIFROID SMH1000 Lyophilizer

Year: 1985

Chamber volume 6500 L
Freeze trap capacity 200 L
Nbr of trays 13
Tray surface 0.8 m²
Minimal T° -75 °C


Essential Guide to Lyophilizers in the Pharmaceutical and Chemical Industries

Lyophilizers, or freeze dryers, are indispensable in the pharmaceutical and chemical industries, essential for preserving and stabilizing sensitive products. This equipment removes water from materials through sublimation, which involves freezing the product, lowering the pressure, and converting ice directly into vapor. This process maintains the product's structure and composition, making lyophilizers vital for producing stable, long-lasting items like vaccines, biological samples, pharmaceuticals, and high-value chemicals.

Types of Lyophilizers

Laboratory Lyophilizers

  • Purpose: Small-scale freeze dryers for research, development, and pilot studies.
  • Applications: Formulation development, small batch production, and academic research.
  • Key Features: Compact design, precise control, and handling of small sample volumes.

Pilot Scale Lyophilizers

  • Purpose: Intermediate scale freeze dryers for process development and small-scale production.
  • Applications: Scale-up studies, process optimization, and limited production runs.
  • Key Features: Larger capacity, advanced control systems, and scalability for production purposes.

Production Scale Lyophilizers

  • Purpose: Large-scale freeze dryers for full-scale manufacturing.
  • Applications: Mass production of pharmaceuticals, biologicals, and chemicals.
  • Key Features: High capacity, robust design, automated operation, and regulatory compliance.

Industrial Lyophilizers

  • Purpose: Freeze dryers designed for industrial applications beyond pharmaceuticals, such as food processing and materials science.
  • Applications: Preservation of food products, stabilization of industrial chemicals, and material processing.
  • Key Features: High throughput, large chamber volumes, and heavy-duty construction.

Key Features and Specifications

When selecting a lyophilizer, consider these critical features and specifications:

  • Capacity: The volume or mass of product the lyophilizer can process per cycle, measured in liters or kilograms.
  • Temperature Range: Operating temperature range, including the lowest achievable shelf and condenser temperatures.
  • Vacuum System: Efficiency and reliability, affecting the drying rate and quality.
  • Control System: Advanced systems for precise monitoring and adjustment of process parameters.
  • Shelf Area and Configurations: Size and number of shelves, determining the total surface area available for product loading.
  • CIP (Clean-in-Place) and SIP (Sterilize-in-Place): Features for automated cleaning and sterilization, essential for maintaining sterility and GMP compliance.
  • Compliance and Validation: Ensure the lyophilizer meets regulatory standards like FDA, EMA, and ISO.
  • Automation and Data Logging: Automated processes and comprehensive data logging for process control, traceability, and validation.

Advantages of Using Lyophilizers

Investing in high-quality lyophilizers provides numerous benefits:

  • Preservation of Product Integrity: Maintains structural and chemical integrity of sensitive products.
  • Extended Shelf Life: Increases the shelf life of perishable materials by removing moisture.
  • Stability: Ensures uniform product quality with stable and consistent drying conditions.
  • Enhanced Purity: Reduces contamination risks, preserving the purity of pharmaceuticals and chemicals.
  • Scalability: Offers scalable solutions from laboratory to production scale.
  • Regulatory Compliance: Meets industry standards and regulations, essential for pharmaceutical and chemical manufacturing.

Considerations When Buying a Lyophilizer

To choose the right lyophilizer, consider these factors:

  • Product Characteristics: Understand the properties of the products to select a lyophilizer with suitable features.
  • Batch Size and Production Volume: Determine the required capacity and scale to match production needs.
  • Temperature and Pressure Requirements: Ensure the lyophilizer can achieve the necessary temperatures and vacuum levels for effective drying.
  • Regulatory Compliance: Verify that the lyophilizer meets all relevant regulatory standards.
  • Space and Installation: Consider space availability and any specific requirements for utilities and infrastructure.
  • Budget: Balance the initial investment with long-term operational costs, including maintenance and energy consumption.
  • Service and Support: Evaluate the availability of technical support, training programs, and maintenance services.
  • Future Expansion: Assess the machine’s scalability to meet potential increases in production demand.

Popular Brands and Pricing

Laboratory Lyophilizers

  • Labconco: Prices range from $10,000 to $50,000.
  • VirTis (SP Scientific): Pricing ranges from $15,000 to $60,000.
  • Millrock Technology: Prices fall between $12,000 and $55,000.

Pilot Scale Lyophilizers

  • GEA Group: Prices range from $50,000 to $200,000.
  • Telstar: Pricing ranges from $60,000 to $250,000.
  • Martin Christ: Prices fall between $55,000 and $220,000.

Production Scale Lyophilizers

  • SP Scientific (VirTis and Hull): Prices range from $200,000 to over $1 million.
  • IMA Life: Pricing ranges from $250,000 to over $1.5 million.
  • HOF Sonderanlagenbau: Prices fall between $300,000 and $2 million.

Industrial Lyophilizers

  • Harvest Right: Prices range from $20,000 to $150,000.
  • Cuddon Freeze Dry: Pricing ranges from $50,000 to $500,000.
  • SP Scientific (VirTis): Prices fall between $100,000 and $700,000.

Conclusion

Lyophilizers, or freeze dryers, are vital for preserving and stabilizing sensitive products in the pharmaceutical and chemical industries. Whether for laboratory research, pilot scale development, full-scale production, or industrial applications, choosing the right lyophilizer depends on specific production needs, product characteristics, and budget. Key factors include capacity, temperature range, vacuum system, control system, shelf area, compliance, and automation features. Leading brands like Labconco, VirTis (SP Scientific), Millrock Technology, GEA Group, Telstar, Martin Christ, IMA Life, HOF Sonderanlagenbau, Harvest Right, and Cuddon Freeze Dry offer high-quality lyophilizers to suit various applications and budgets. By carefully evaluating production requirements, product characteristics, and budget, businesses can invest in the right lyophilizer to enhance their production capabilities and ensure consistent, high-quality results.